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Although localized pain may occur in advanced cancer, the initial swelling is usually painless.Some cancers can cause a buildup of fluid within the chest or abdomen.However, cancer 'seeds' grow in certain selected site only ('soil') as hypothesized in the soil and seed hypothesis of cancer metastasis.The symptoms of metastatic cancers depend on the tumor location and can include enlarged lymph nodes (which can be felt or sometimes seen under the skin and are typically hard), enlarged liver or enlarged spleen, which can be felt in the abdomen, pain or fracture of affected bones and neurological symptoms.Local symptoms may occur due to the mass of the tumor or its ulceration.For example, mass effects from lung cancer can block the bronchus resulting in cough or pneumonia; esophageal cancer can cause narrowing of the esophagus, making it difficult or painful to swallow; and colorectal cancer may lead to narrowing or blockages in the bowel, affecting bowel habits.

Cancer can spread from its original site by local spread, lymphatic spread to regional lymph nodes or by haematogenous spread via the blood to distant sites, known as metastasis.

When cancer spreads by a haematogenous route, it usually spreads all over the body.

Masses in breasts or testicles may produce observable lumps.

Ulceration can cause bleeding that, if it occurs in the lung, will lead to coughing up blood, in the bowels to anemia or rectal bleeding, in the bladder to blood in the urine and in the uterus to vaginal bleeding.

In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. Signs and symptoms appear as the mass grows or ulcerates.

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The findings that result depend on the cancer's type and location. Many frequently occur in individuals who have other conditions. Thus, it is common for people diagnosed with cancer to have been treated for other diseases, which were hypothesized to be causing their symptoms.

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